Start by rubbing the brisket down with a mixture of liquid smoke and Worcestershire sauce.
In a small dish, mix the smoked paprika, garlic, onion, and mustard powders with the salt and pepper. Rub the spice mixture all over the brisket.
Seal everything up in a bag and drop the brisket into a 133 degree water bath for 48 hours.
Finish the brisket on a medium-high grill for 8 to 10 minutes, turning the brisket regularly. The goal is to develop a nice bark on the outside without overcooking the meat.
To serve the brisket, thinly slice it and serve it with a good BBQ sauce on the side.